FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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4 compounds in matrix 9 best compound-target hits listed 9 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T02T03T05T07T10T12T14T17T21
TC321 0.940 0.926 2 0.94 0.91
TC321 0.875 0.848 2 0.82 0.87
TC321 0.855 0.808 4 0.82 0.85 0.81 0.75
TC321 0.812 0.812 1 0.81

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
TC321 T10
native IFP available
T10
selection_import_t10
0.940 1.000 0.827 native_similarity final_rank_score -13.0257 -0.681828 17 10 Pose
TC321 T21
native IFP available
T21
selection_import_t21
0.912 1.000 0.748 native_similarity final_rank_score -19.5434 -0.671874 18 11 Pose
TC321 T12
native IFP available
T12
selection_import_t12
0.875 1.000 0.643 native_similarity final_rank_score -23.2021 -0.726178 18 12 Pose
TC321 T07
native IFP available
T07
selection_import_t07
0.855 1.000 0.585 native_similarity final_rank_score -29.4206 -0.814257 18 7 Pose
TC321 T05
native IFP available
T05
selection_import_t05
0.821 1.000 0.487 native_similarity final_rank_score -23.241 -0.714587 14 5 Pose
TC321 T03
native IFP available
T03
selection_import_t03
0.820 1.000 0.485 native_similarity final_rank_score -25.7326 -0.881205 20 5 Pose
TC321 T02
native IFP available
T02
selection_import_t02
0.812 1.000 0.464 native_similarity final_rank_score -25.7718 -0.728023 18 1 Pose
TC321 T14
native IFP available
T14
selection_import_t14
0.806 1.000 0.447 native_similarity final_rank_score -21.7902 -0.585103 19 11 Pose
TC321 T17
native IFP available
T17
selection_import_t17
0.750 1.000 0.287 native_similarity final_rank_score -19.5422 -0.597329 20 6 Pose