FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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1 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T10T14T15T20
OHD_TC1_48 0.858 0.816 4 0.86 0.80 0.80 0.80

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
OHD_TC1_48 T10
native IFP available
T10
selection_import_t10
0.858 1.000 0.595 native_similarity final_rank_score -25.72 -0.793061 17 7 Pose
OHD_TC1_48 T15
native IFP available
T15
selection_import_t15
0.804 1.000 0.441 native_similarity final_rank_score -25.9386 -0.791134 16 4 Pose
OHD_TC1_48 T14
native IFP available
T14
selection_import_t14
0.804 1.000 0.440 native_similarity final_rank_score -24.8488 -0.753449 13 4 Pose
OHD_TC1_48 T20
native IFP available
T20
selection_import_t20
0.799 1.000 0.425 native_similarity final_rank_score -19.6021 -0.60838 10 6 Pose