FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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1 compounds in matrix 5 best compound-target hits listed 5 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T07T08T09T13T19
OHD_TC1_162 0.930 0.830 5 0.84 0.82 0.80 0.93 0.76

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
OHD_TC1_162 T13
native IFP available
T13
selection_import_t13
0.930 1.000 0.801 native_similarity final_rank_score -22.3234 -1.05152 19 12 Pose
OHD_TC1_162 T07
native IFP available
T07
selection_import_t07
0.841 1.000 0.547 native_similarity final_rank_score -30.3659 -1.17939 20 7 Pose
OHD_TC1_162 T08
native IFP available
T08
selection_import_t08
0.819 1.000 0.482 native_similarity final_rank_score -31.2941 -1.2265 18 6 Pose
OHD_TC1_162 T09
native IFP available
T09
selection_import_t09
0.802 1.000 0.436 native_similarity final_rank_score -25.0303 -1.02358 18 6 Pose
OHD_TC1_162 T19
native IFP available
T19
selection_import_t19
0.756 1.000 0.302 native_similarity final_rank_score -30.2153 -1.24401 19 6 Pose