FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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1 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T05T07T08T21
OHD_MAC_55 0.915 0.883 4 0.84 0.88 0.92 0.90

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
OHD_MAC_55 T08
native IFP available
T08
selection_import_t08
0.915 1.000 0.758 native_similarity final_rank_score -31.1122 -1.43305 19 14 Pose
OHD_MAC_55 T21
native IFP available
T21
selection_import_t21
0.903 1.000 0.723 native_similarity final_rank_score -25.7496 -1.18497 16 15 Pose
OHD_MAC_55 T07
native IFP available
T07
selection_import_t07
0.876 1.000 0.645 native_similarity final_rank_score -25.7417 -1.28846 20 11 Pose
OHD_MAC_55 T05
native IFP available
T05
selection_import_t05
0.838 1.000 0.537 native_similarity final_rank_score -23.5365 -1.19834 17 10 Pose