FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 7 best compound-target hits listed 7 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T14T15T16T18T19T20
KB_HAT_98 0.929 0.845 5 0.89 0.83 0.81 0.76 0.93
KB_HAT_98 0.820 0.814 2 0.81 0.82

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
KB_HAT_98 T20
native IFP available
T20
selection_import_t20
0.929 1.000 0.796 native_similarity final_rank_score -23.6303 -0.766642 11 7 Pose
KB_HAT_98 T03
native IFP available
T03
selection_import_t03
0.895 1.000 0.699 native_similarity final_rank_score -24.8124 -1.03678 18 4 Pose
KB_HAT_98 T15
native IFP available
T15
selection_import_t15
0.829 1.000 0.513 native_similarity final_rank_score -27.572 -0.968109 15 7 Pose
KB_HAT_98 T16
native IFP available
T16
selection_import_t16
0.820 1.000 0.485 native_similarity final_rank_score -20.4226 -0.893989 15 9 Pose
KB_HAT_98 T14
native IFP available
T14
selection_import_t14
0.809 1.000 0.453 native_similarity final_rank_score -23.5077 -0.920236 13 8 Pose
KB_HAT_98 T18
native IFP available
T18
selection_import_t18
0.807 1.000 0.448 native_similarity final_rank_score -24.789 -0.863675 11 5 Pose
KB_HAT_98 T19
native IFP available
T19
selection_import_t19
0.765 1.000 0.327 native_similarity final_rank_score -35.8251 -1.2851 19 9 Pose