FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB Docking_panel_21Explorer results are being read from this database.
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1 compounds in matrix 2 best compound-target hits listed 2 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T07T20
ulfkktlib_2067
[H]Oc1cccc(N([H])/C=C2/C(=O)OC[C@H]2N([H])C(=O)OCc2ccccc2)c1
0.945 0.898 2 0.85 0.94

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
ulfkktlib_2067
[H]Oc1cccc(N([H])/C=C2/C(=O)OC[C@H]2N([H])C(=O)OCc2ccccc2)c1
T20
native IFP available
T20
dockmulti_91311c650f2e_T20
0.945 1.000 0.842 native_similarity final_rank_score -15.9771 -0.694609 9 8 Pose
ulfkktlib_2067
[H]Oc1cccc(N([H])/C=C2/C(=O)OC[C@H]2N([H])C(=O)OCc2ccccc2)c1
T07
native IFP available
T07
dockmulti_91311c650f2e_T07
0.851 1.000 0.573 native_similarity final_rank_score -24.2679 -1.17414 15 6 Pose