FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 15 best compound-target hits listed 15 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T03T05T08T12T14T15T16T17T18T19T20T21T22
Z57907181 0.925 0.827 6 0.93 0.78 0.85 0.82 0.71 0.87
Z57907181 0.912 0.846 9 0.84 0.80 0.80 0.91 0.85 0.74 0.88 0.91 0.87

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z57907181 T12
native IFP available
T12
selection_import_t12
0.925 1.000 0.787 native_similarity final_rank_score -28.4625 -0.775005 19 10 Pose
Z57907181 T20
native IFP available
T20
selection_import_t20
0.912 1.000 0.749 native_similarity final_rank_score -19.8317 -0.570175 14 8 Pose
Z57907181 T05
native IFP available
T05
selection_import_t05
0.909 1.000 0.740 native_similarity final_rank_score -26.3534 -0.802078 17 9 Pose
Z57907181 T17
native IFP available
T17
selection_import_t17
0.884 1.000 0.668 native_similarity final_rank_score -22.2468 -0.6624 15 4 Pose
Z57907181 T21
native IFP available
T21
selection_import_t21
0.873 1.000 0.637 native_similarity final_rank_score -26.2033 -0.731415 17 9 Pose
Z57907181 T22
native IFP available
T22
selection_import_t22
0.873 1.000 0.636 native_similarity final_rank_score -25.7507 -0.883803 22 11 Pose
Z57907181 T15
native IFP available
T15
selection_import_t15
0.852 1.000 0.577 native_similarity final_rank_score -26.1886 -0.773538 15 7 Pose
Z57907181 T08
native IFP available
T08
selection_import_t08
0.850 1.000 0.571 native_similarity final_rank_score -24.3858 -0.955819 17 6 Pose
Z57907181 T01
native IFP available
T01
selection_import_t01
0.844 1.000 0.555 native_similarity final_rank_score -24.0163 -0.793299 19 4 Pose
Z57907181 T18
native IFP available
T18
selection_import_t18
0.824 1.000 0.497 native_similarity final_rank_score -21.9414 -0.613323 12 7 Pose
Z57907181 T03
native IFP available
T03
selection_import_t03
0.802 1.000 0.435 native_similarity final_rank_score -22.6994 -0.81133 12 5 Pose
Z57907181 T02
native IFP available
T02
selection_import_t02
0.802 1.000 0.433 native_similarity final_rank_score -21.3513 -0.741241 17 3 Pose
Z57907181 T14
native IFP available
T14
selection_import_t14
0.778 1.000 0.365 native_similarity final_rank_score -15.0669 -0.624919 15 8 Pose
Z57907181 T16
native IFP available
T16
selection_import_t16
0.741 1.000 0.259 native_similarity final_rank_score -24.2896 -0.725292 16 4 Pose
Z57907181 T19
native IFP available
T19
selection_import_t19
0.710 1.000 0.171 native_similarity final_rank_score -30.6534 -1.04339 20 8 Pose