FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 6 best compound-target hits listed 6 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T02T09T13T14T20T22
Z56831485 0.923 0.847 6 0.84 0.80 0.92 0.83 0.80 0.89

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56831485 T13
native IFP available
T13
selection_import_t13
0.923 1.000 0.780 native_similarity final_rank_score -25.0007 -0.976484 18 8 Pose
Z56831485 T22
native IFP available
T22
selection_import_t22
0.886 1.000 0.675 native_similarity final_rank_score -29.6046 -1.19062 21 9 Pose
Z56831485 T02
native IFP available
T02
selection_import_t02
0.841 1.000 0.545 native_similarity final_rank_score -24.6402 -0.84976 20 1 Pose
Z56831485 T14
native IFP available
T14
selection_import_t14
0.832 1.000 0.520 native_similarity final_rank_score -18.014 -0.743307 15 6 Pose
Z56831485 T20
native IFP available
T20
selection_import_t20
0.799 1.000 0.425 native_similarity final_rank_score -17.0492 -0.63605 10 4 Pose
Z56831485 T09
native IFP available
T09
selection_import_t09
0.798 1.000 0.424 native_similarity final_rank_score -18.7227 -0.844482 18 5 Pose