FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T06T09
Z56578031 0.852 0.852 1 0.85
Z56578031 0.844 0.837 2 0.84 0.83

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56578031 T09
native IFP available
T09
selection_import_t09
0.852 1.000 0.576 native_similarity final_rank_score -29.9751 -0.765876 20 2 Pose
Z56578031 T01
native IFP available
T01
selection_import_t01
0.844 1.000 0.555 native_similarity final_rank_score -22.4629 -0.791814 19 3 Pose
Z56578031 T06
native IFP available
T06
selection_import_t06
0.830 1.000 0.515 native_similarity final_rank_score -15.6824 -0.664259 21 1 Pose