FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 8 best compound-target hits listed 8 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T02T03T06T07T09T17T18T21
Z56575886 0.857 0.827 4 0.85 0.86 0.77 0.83
Z56575886 0.824 0.813 4 0.80 0.81 0.82 0.82

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56575886 T07
native IFP available
T07
selection_import_t07
0.857 1.000 0.593 native_similarity final_rank_score -28.0315 -0.939978 17 2 Pose
Z56575886 T02
native IFP available
T02
selection_import_t02
0.850 1.000 0.570 native_similarity final_rank_score -23.4592 -0.899914 20 1 Pose
Z56575886 T17
native IFP available
T17
selection_import_t17
0.827 1.000 0.507 native_similarity final_rank_score -17.0795 -0.697649 18 2 Pose
Z56575886 T18
native IFP available
T18
selection_import_t18
0.824 1.000 0.497 native_similarity final_rank_score -20.8408 -0.708222 12 2 Pose
Z56575886 T21
native IFP available
T21
selection_import_t21
0.816 1.000 0.474 native_similarity final_rank_score -20.7444 -0.823463 12 10 Pose
Z56575886 T06
native IFP available
T06
selection_import_t06
0.809 1.000 0.454 native_similarity final_rank_score -21.31 -0.842285 19 1 Pose
Z56575886 T03
native IFP available
T03
selection_import_t03
0.801 1.000 0.432 native_similarity final_rank_score -26.105 -0.924225 17 2 Pose
Z56575886 T09
native IFP available
T09
selection_import_t09
0.775 1.000 0.356 native_similarity final_rank_score -24.5626 -0.877617 17 3 Pose