FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T11T14T20
Z56262886 0.953 0.872 3 0.87 0.80 0.95

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56262886 T20
native IFP available
T20
selection_import_t20
0.953 1.000 0.867 native_similarity final_rank_score -17.7389 -0.575177 12 5 Pose
Z56262886 T11
native IFP available
T11
selection_import_t11
0.867 1.000 0.620 native_similarity final_rank_score -23.7817 -0.716498 14 5 Pose
Z56262886 T14
native IFP available
T14
selection_import_t14
0.796 1.000 0.417 native_similarity final_rank_score -16.3602 -0.672691 17 5 Pose