FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB Docking_panel_21Explorer results are being read from this database.
Reset
2 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T02T12T14
Z56175938
[H]N(c1cccc(Cl)c1)[C@@H](c1ccncc1)c1ccc2cccnc2c1O
0.866 0.866 1 0.87
Z56175938
[H]N(c1cccc(Cl)c1)[C@H](c1ccncc1)c1ccc2cccnc2c1O
0.819 0.800 2 0.82 0.78

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56175938
[H]N(c1cccc(Cl)c1)[C@@H](c1ccncc1)c1ccc2cccnc2c1O
T12
native IFP available
T12
dockmulti_91311c650f2e_T12
0.866 1.000 0.617 native_similarity final_rank_score -18.3693 -0.75151 16 7 Pose
Z56175938
[H]N(c1cccc(Cl)c1)[C@H](c1ccncc1)c1ccc2cccnc2c1O
T02
native IFP available
T02
dockmulti_91311c650f2e_T02
0.819 1.000 0.484 native_similarity final_rank_score -23.9548 -0.911925 18 1 Pose
Z56175938
[H]N(c1cccc(Cl)c1)[C@H](c1ccncc1)c1ccc2cccnc2c1O
T14
native IFP available
T14
dockmulti_91311c650f2e_T14
0.781 1.000 0.375 native_similarity final_rank_score -15.3236 -0.633199 8 7 Pose