FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
Reset
2 compounds in matrix 15 best compound-target hits listed 15 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T03T07T08T09T12T13T14T15T16T17T19T20T22
Z49734016 0.962 0.825 5 0.79 0.73 0.77 0.96 0.87
Z49734016 0.911 0.822 10 0.82 0.82 0.77 0.86 0.83 0.79 0.91 0.87 0.78 0.77

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z49734016 T20
native IFP available
T20
selection_import_t20
0.962 1.000 0.891 native_similarity final_rank_score -19.561 -0.728846 11 7 Pose
Z49734016 T12
native IFP available
T12
selection_import_t12
0.911 1.000 0.745 native_similarity final_rank_score -20.9833 -0.924269 17 10 Pose
Z49734016 T22
native IFP available
T22
selection_import_t22
0.874 1.000 0.641 native_similarity final_rank_score -28.4808 -1.14047 22 7 Pose
Z49734016 T13
native IFP available
T13
selection_import_t13
0.867 1.000 0.620 native_similarity final_rank_score -29.341 -0.960121 21 8 Pose
Z49734016 T07
native IFP available
T07
selection_import_t07
0.859 1.000 0.597 native_similarity final_rank_score -35.5526 -1.184 21 9 Pose
Z49734016 T08
native IFP available
T08
selection_import_t08
0.828 1.000 0.508 native_similarity final_rank_score -33.0798 -1.21427 15 7 Pose
Z49734016 T01
native IFP available
T01
selection_import_t01
0.823 1.000 0.493 native_similarity final_rank_score -27.4092 -0.922927 17 3 Pose
Z49734016 T02
native IFP available
T02
selection_import_t02
0.822 1.000 0.491 native_similarity final_rank_score -27.1396 -0.961824 15 3 Pose
Z49734016 T14
native IFP available
T14
selection_import_t14
0.793 1.000 0.408 native_similarity final_rank_score -21.2984 -0.800422 18 5 Pose
Z49734016 T09
native IFP available
T09
selection_import_t09
0.792 1.000 0.406 native_similarity final_rank_score -24.472 -0.905103 17 7 Pose
Z49734016 T15
native IFP available
T15
selection_import_t15
0.780 1.000 0.373 native_similarity final_rank_score -25.6648 -0.827527 12 7 Pose
Z49734016 T19
native IFP available
T19
selection_import_t19
0.772 1.000 0.350 native_similarity final_rank_score -29.6637 -1.13381 12 7 Pose
Z49734016 T17
native IFP available
T17
selection_import_t17
0.769 1.000 0.339 native_similarity final_rank_score -22.0048 -0.856245 19 5 Pose
Z49734016 T03
native IFP available
T03
selection_import_t03
0.767 1.000 0.333 native_similarity final_rank_score -27.7016 -0.959762 15 9 Pose
Z49734016 T16
native IFP available
T16
selection_import_t16
0.729 1.000 0.225 native_similarity final_rank_score -24.4732 -0.784032 13 6 Pose