FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
Reset
2 compounds in matrix 13 best compound-target hits listed 13 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T04T06T07T08T09T11T12T13T15T16T17T21T22
Z49597668 0.935 0.829 8 0.82 0.80 0.77 0.93 0.90 0.76 0.74 0.91
Z49597668 0.902 0.858 5 0.86 0.84 0.89 0.80 0.90

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z49597668 T12
native IFP available
T12
selection_import_t12
0.935 1.000 0.814 native_similarity final_rank_score -26.9697 -0.991393 16 8 Pose
Z49597668 T22
native IFP available
T22
selection_import_t22
0.913 1.000 0.752 native_similarity final_rank_score -28.7845 -1.10643 22 11 Pose
Z49597668 T21
native IFP available
T21
selection_import_t21
0.902 1.000 0.720 native_similarity final_rank_score -21.4421 -0.962335 16 10 Pose
Z49597668 T13
native IFP available
T13
selection_import_t13
0.897 1.000 0.705 native_similarity final_rank_score -24.2501 -0.990361 21 9 Pose
Z49597668 T11
native IFP available
T11
selection_import_t11
0.893 1.000 0.695 native_similarity final_rank_score -19.3548 -0.866308 17 3 Pose
Z49597668 T07
native IFP available
T07
selection_import_t07
0.862 1.000 0.605 native_similarity final_rank_score -33.6293 -1.27557 18 6 Pose
Z49597668 T08
native IFP available
T08
selection_import_t08
0.836 1.000 0.531 native_similarity final_rank_score -32.6851 -1.23737 17 5 Pose
Z49597668 T04
native IFP available
T04
selection_import_t04
0.816 1.000 0.474 native_similarity final_rank_score -31.2434 -0.922035 12 3 Pose
Z49597668 T06
native IFP available
T06
selection_import_t06
0.798 1.000 0.424 native_similarity final_rank_score -26.6835 -0.818645 18 2 Pose
Z49597668 T15
native IFP available
T15
selection_import_t15
0.797 1.000 0.419 native_similarity final_rank_score -22.5455 -0.863483 13 5 Pose
Z49597668 T09
native IFP available
T09
selection_import_t09
0.772 1.000 0.349 native_similarity final_rank_score -26.0195 -0.919535 18 7 Pose
Z49597668 T16
native IFP available
T16
selection_import_t16
0.755 1.000 0.300 native_similarity final_rank_score -22.2922 -0.831817 10 5 Pose
Z49597668 T17
native IFP available
T17
selection_import_t17
0.743 1.000 0.264 native_similarity final_rank_score -22.5883 -0.846877 15 4 Pose