FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB Docking_panel_21Explorer results are being read from this database.
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2 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T07T11T15T20
Z46063496
[H]n1c(/C(C#N)=C\c2cn(-c3ccccc3)nc2-c2cc3ccccc3o2)nc2ccccc21
0.946 0.907 2 0.87 0.95
Z46063496
[H]n1c(/C(C#N)=C/c2cn(-c3ccccc3)nc2-c2cc3ccccc3o2)nc2ccccc21
0.829 0.819 2 0.81 0.83

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z46063496
[H]n1c(/C(C#N)=C\c2cn(-c3ccccc3)nc2-c2cc3ccccc3o2)nc2ccccc21
T20
native IFP available
T20
dockmulti_91311c650f2e_T20
0.946 1.000 0.846 native_similarity final_rank_score -18.3929 -0.529183 13 4 Pose
Z46063496
[H]n1c(/C(C#N)=C\c2cn(-c3ccccc3)nc2-c2cc3ccccc3o2)nc2ccccc21
T11
native IFP available
T11
dockmulti_91311c650f2e_T11
0.868 1.000 0.622 native_similarity final_rank_score -17.0144 -0.583165 12 3 Pose
Z46063496
[H]n1c(/C(C#N)=C/c2cn(-c3ccccc3)nc2-c2cc3ccccc3o2)nc2ccccc21
T15
native IFP available
T15
dockmulti_91311c650f2e_T15
0.829 1.000 0.513 native_similarity final_rank_score -24.4977 -0.751138 15 1 Pose
Z46063496
[H]n1c(/C(C#N)=C/c2cn(-c3ccccc3)nc2-c2cc3ccccc3o2)nc2ccccc21
T07
native IFP available
T07
dockmulti_91311c650f2e_T07
0.809 1.000 0.453 native_similarity final_rank_score -19.9244 -0.532419 15 0 Pose