FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 5 best compound-target hits listed 5 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T02T09T11T14T19
Z32749009 0.858 0.819 5 0.84 0.86 0.86 0.79 0.75

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z32749009 T09
native IFP available
T09
selection_import_t09
0.858 1.000 0.595 native_similarity final_rank_score -21.5206 -0.825933 19 3 Pose
Z32749009 T11
native IFP available
T11
selection_import_t11
0.858 1.000 0.594 native_similarity final_rank_score -29.7728 -0.880778 16 3 Pose
Z32749009 T02
native IFP available
T02
selection_import_t02
0.844 1.000 0.553 native_similarity final_rank_score -25.4239 -0.835204 17 2 Pose
Z32749009 T14
native IFP available
T14
selection_import_t14
0.789 1.000 0.397 native_similarity final_rank_score -21.4009 -0.735347 17 5 Pose
Z32749009 T19
native IFP available
T19
selection_import_t19
0.745 1.000 0.272 native_similarity final_rank_score -29.0756 -1.02776 22 4 Pose