FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB Docking_panel_21Explorer results are being read from this database.
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1 compounds in matrix 2 best compound-target hits listed 2 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T07T20
Z31231479
[H]N(c1cccc(C(C)=O)c1)c1nc(-c2cccnc2)nc2ccccc12
0.936 0.895 2 0.85 0.94

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z31231479
[H]N(c1cccc(C(C)=O)c1)c1nc(-c2cccnc2)nc2ccccc12
T20
native IFP available
T20
dockmulti_91311c650f2e_T20
0.936 1.000 0.817 native_similarity final_rank_score -13.8824 -0.695962 10 5 Pose
Z31231479
[H]N(c1cccc(C(C)=O)c1)c1nc(-c2cccnc2)nc2ccccc12
T07
native IFP available
T07
dockmulti_91311c650f2e_T07
0.855 1.000 0.585 native_similarity final_rank_score -28.2016 -1.29225 18 5 Pose