FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB Docking_panel_21Explorer results are being read from this database.
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2 compounds in matrix 2 best compound-target hits listed 2 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T18T20
Z27056998
[H]N(C(C)=O)c1ccc(-c2csc(/N=C(\O)[C@@H]3CC(=O)N(c4ccc5c(c4)OCCO5)C3)n2)cc1
0.857 0.857 1 0.86
Z27056998
[H]N(C(C)=O)c1ccc(-c2csc(N([H])C(=O)[C@H]3CC(=O)N(c4ccc5c(c4)OCCO5)C3)n2)cc1
0.797 0.797 1 0.80

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z27056998
[H]N(C(C)=O)c1ccc(-c2csc(/N=C(\O)[C@@H]3CC(=O)N(c4ccc5c(c4)OCCO5)C3)n2)cc1
T20
native IFP available
T20
dockmulti_91311c650f2e_T20
0.857 1.000 0.591 native_similarity final_rank_score -23.3699 -0.466072 11 5 Pose
Z27056998
[H]N(C(C)=O)c1ccc(-c2csc(N([H])C(=O)[C@H]3CC(=O)N(c4ccc5c(c4)OCCO5)C3)n2)cc1
T18
native IFP available
T18
dockmulti_91311c650f2e_T18
0.797 1.000 0.419 native_similarity final_rank_score -20.3656 -0.585577 13 2 Pose