FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 11 best compound-target hits listed 11 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T03T05T06T09T11T12T14T17T18
Z24314037 0.922 0.826 8 0.78 0.84 0.85 0.84 0.75 0.84 0.92 0.77
Z24314037 0.855 0.824 3 0.85 0.81 0.81

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z24314037 T12
native IFP available
T12
selection_import_t12
0.922 1.000 0.777 native_similarity final_rank_score -30.8704 -1.09275 18 12 Pose
Z24314037 T05
native IFP available
T05
selection_import_t05
0.855 1.000 0.586 native_similarity final_rank_score -31.9693 -1.04503 13 7 Pose
Z24314037 T03
native IFP available
T03
selection_import_t03
0.850 1.000 0.571 native_similarity final_rank_score -23.148 -1.01988 16 6 Pose
Z24314037 T11
native IFP available
T11
selection_import_t11
0.844 1.000 0.555 native_similarity final_rank_score -22.1631 -0.832557 14 7 Pose
Z24314037 T06
native IFP available
T06
selection_import_t06
0.843 1.000 0.551 native_similarity final_rank_score -21.2069 -0.829155 20 2 Pose
Z24314037 T02
native IFP available
T02
selection_import_t02
0.838 1.000 0.539 native_similarity final_rank_score -26.3858 -0.821749 19 2 Pose
Z24314037 T18
native IFP available
T18
selection_import_t18
0.809 1.000 0.453 native_similarity final_rank_score -22.4599 -0.70632 15 3 Pose
Z24314037 T14
native IFP available
T14
selection_import_t14
0.807 1.000 0.450 native_similarity final_rank_score -22.8777 -0.711854 18 4 Pose
Z24314037 T01
native IFP available
T01
selection_import_t01
0.780 1.000 0.371 native_similarity final_rank_score -23.6939 -0.830868 15 6 Pose
Z24314037 T17
native IFP available
T17
selection_import_t17
0.773 1.000 0.352 native_similarity final_rank_score -20.6957 -0.784492 17 6 Pose
Z24314037 T09
native IFP available
T09
selection_import_t09
0.754 1.000 0.297 native_similarity final_rank_score -23.0816 -0.816146 15 5 Pose