FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 5 best compound-target hits listed 5 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T03T14T16
Z19540043 0.919 0.906 2 0.92 0.89
Z19540043 0.876 0.807 3 0.88 0.77 0.77

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z19540043 T01
native IFP available
T01
selection_import_t01
0.919 1.000 0.768 native_similarity final_rank_score -23.0501 -0.671083 22 5 Pose
Z19540043 T02
native IFP available
T02
selection_import_t02
0.893 1.000 0.695 native_similarity final_rank_score -25.6467 -0.657735 23 4 Pose
Z19540043 T03
native IFP available
T03
selection_import_t03
0.876 1.000 0.645 native_similarity final_rank_score -29.0255 -0.718477 16 7 Pose
Z19540043 T16
native IFP available
T16
selection_import_t16
0.773 1.000 0.352 native_similarity final_rank_score -26.825 -0.617312 17 3 Pose
Z19540043 T14
native IFP available
T14
selection_import_t14
0.772 1.000 0.348 native_similarity final_rank_score -18.1212 -0.604217 18 4 Pose