FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB Docking_panel_21Explorer results are being read from this database.
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1 compounds in matrix 1 best compound-target hits listed 1 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T18
Z1741977105
[H][N@+]1(Cc2ccccc2)CC[C@H](C[C@H]2Cc3cc(OC)c(OC)cc3C2=O)CC1
0.824 0.824 1 0.82

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z1741977105
[H][N@+]1(Cc2ccccc2)CC[C@H](C[C@H]2Cc3cc(OC)c(OC)cc3C2=O)CC1
T18
native IFP available
T18
dockmulti_91311c650f2e_T18
0.824 1.000 0.498 native_similarity final_rank_score -17.2291 -0.697364 16 1 Pose