FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB Docking_panel_21Explorer results are being read from this database.
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2 compounds in matrix 5 best compound-target hits listed 5 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T11T13T14T20T21
TC391
[H]Oc1ccc(CCc2cc([C@@]3(C)CSc4c(C)c(O[H])c(C)c(C)c4O3)on2)cc1O[H]
0.920 0.866 2 0.81 0.92
TC391
[H]Oc1ccc(CCc2cc([C@]3(C)CSc4c(C)c(O[H])c(C)c(C)c4O3)on2)cc1O[H]
0.858 0.833 3 0.82 0.86 0.82

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
TC391
[H]Oc1ccc(CCc2cc([C@@]3(C)CSc4c(C)c(O[H])c(C)c(C)c4O3)on2)cc1O[H]
T21
native IFP available
T21
dockmulti_91311c650f2e_T21
0.920 1.000 0.771 native_similarity final_rank_score -26.4394 -0.991679 16 11 Pose
TC391
[H]Oc1ccc(CCc2cc([C@]3(C)CSc4c(C)c(O[H])c(C)c(C)c4O3)on2)cc1O[H]
T13
native IFP available
T13
dockmulti_91311c650f2e_T13
0.858 1.000 0.593 native_similarity final_rank_score -23.9123 -0.980978 18 8 Pose
TC391
[H]Oc1ccc(CCc2cc([C@]3(C)CSc4c(C)c(O[H])c(C)c(C)c4O3)on2)cc1O[H]
T11
native IFP available
T11
dockmulti_91311c650f2e_T11
0.824 1.000 0.498 native_similarity final_rank_score -22.7724 -1.00163 19 5 Pose
TC391
[H]Oc1ccc(CCc2cc([C@]3(C)CSc4c(C)c(O[H])c(C)c(C)c4O3)on2)cc1O[H]
T14
native IFP available
T14
dockmulti_91311c650f2e_T14
0.818 1.000 0.480 native_similarity final_rank_score -17.981 -0.828299 15 8 Pose
TC391
[H]Oc1ccc(CCc2cc([C@@]3(C)CSc4c(C)c(O[H])c(C)c(C)c4O3)on2)cc1O[H]
T20
native IFP available
T20
dockmulti_91311c650f2e_T20
0.812 1.000 0.463 native_similarity final_rank_score -16.9623 -0.669226 13 6 Pose