FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T11T12T22
TC323
[H]N([H])S(=O)(=O)c1ccc(CC[N+]([H])([H])Cc2cccnc2)cc1
0.896 0.893 2 0.90 0.89
TC323
[H]N(CCc1ccc(S(=O)(=O)N([H])[H])cc1)Cc1cccnc1
0.854 0.854 1 0.85

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
TC323
[H]N([H])S(=O)(=O)c1ccc(CC[N+]([H])([H])Cc2cccnc2)cc1
T12
native IFP available
T12
selection_import_t12
0.896 1.000 0.702 native_similarity final_rank_score -28.3857 -1.4654 18 11 Pose
TC323
[H]N([H])S(=O)(=O)c1ccc(CC[N+]([H])([H])Cc2cccnc2)cc1
T22
native IFP available
T22
selection_import_t22
0.889 1.000 0.684 native_similarity final_rank_score -35.225 -1.93509 19 12 Pose
TC323
[H]N(CCc1ccc(S(=O)(=O)N([H])[H])cc1)Cc1cccnc1
T11
native IFP available
T11
selection_import_t11
0.854 1.000 0.583 native_similarity final_rank_score -23.9325 -1.32618 17 5 Pose