FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB Docking_panel_21Explorer results are being read from this database.
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2 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T02T04T12
MK218
[H]Oc1ccc(CCn2cc(C[C@@]3(C)CCc4c(C)c(O[H])c(C)c(C)c4O3)nn2)cc1O[H]
0.875 0.875 1 0.87
MK218
[H]Oc1ccc(CCn2cc(C[C@]3(C)CCc4c(C)c(O[H])c(C)c(C)c4O3)nn2)cc1O[H]
0.855 0.832 2 0.81 0.85

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
MK218
[H]Oc1ccc(CCn2cc(C[C@@]3(C)CCc4c(C)c(O[H])c(C)c(C)c4O3)nn2)cc1O[H]
T12
native IFP available
T12
dockmulti_91311c650f2e_T12
0.875 1.000 0.643 native_similarity final_rank_score -19.7948 -0.872999 15 8 Pose
MK218
[H]Oc1ccc(CCn2cc(C[C@]3(C)CCc4c(C)c(O[H])c(C)c(C)c4O3)nn2)cc1O[H]
T04
native IFP available
T04
dockmulti_91311c650f2e_T04
0.855 1.000 0.585 native_similarity final_rank_score -17.4083 -0.662661 14 8 Pose
MK218
[H]Oc1ccc(CCn2cc(C[C@]3(C)CCc4c(C)c(O[H])c(C)c(C)c4O3)nn2)cc1O[H]
T02
native IFP available
T02
dockmulti_91311c650f2e_T02
0.809 1.000 0.454 native_similarity final_rank_score -20.6112 -0.892143 19 3 Pose