FAIRMol

OSA_Lib_61

Pose ID 35649 Compound 2850 Pose 1008

DB Docking_panel_21Docking pose analysis is being read from this database.
Molecular metrics status: queued
Pose metrics recompute is queued in the background.
Metrics cached · SASA missing
T16
Trypanothione reductase (TryR / TR) Trypanosoma brucei
Ligand OSA_Lib_61
PDB6RB5

3D complex viewer

Strict H-bonds Permissive H-bonds
Viewer legend
Protein receptor
Pocket residues
Cofactor context
Docked ligand
Overall assessment
Reject No SASA yet
Promising but geometrically suspicious
Binding strong Geometry low Native strong SASA missing
Strain ΔE
15.6 kcal/mol
Protein clashes
6
Internal clashes
6
Native overlap
contact recall 0.83, Jaccard 0.56
Burial
100%
Reason: 6 internal clashes
6 protein-contact clashes 6 intramolecular clashes

Interaction summary

HB 0 HY 24 PI 0 CLASH 6
Final rank5.893Score-21.156
Inter norm-0.678Intra norm-0.005
Top1000noExcludedno
Contacts16H-bonds0
Artifact reasongeometry warning; 13 clashes; 12 protein contact clashes; moderate strain Δ 15.6
Residues
ALA209 ALA67 ALA90 ARG74 ASN208 GLY66 GLY85 LEU73 LYS211 LYS89 MET70 PHE83 PRO212 PRO213 TYR69 VAL88

Protein summary

493 residues
Protein targetT16Atoms7551
Residues493Chains1
Residue summaryVAL:768; LYS:704; LEU:703; ILE:532; GLU:450; THR:434; ARG:408; PHE:400; ALA:390; ASN:350; PRO:350; GLY:336; SER:319; TYR:294; ASP:276; MET:221

Receptor context

1 kept / 0 excluded
Receptor context filtering: interactions and SASA are computed against protein atoms plus allowed cofactors/ions. Native ligand-like HETATM partners are excluded from scoring.
Kept context 1 Excluded HETATM 0
Kept cofactors / ions
A:FAD501

Native ligand reference

★ reference
Interaction fingerprint calculated directly from the uploaded native ligand without docking. Current H-bond mode: strict.
Name6RB5Contacts12
PoseOpen native poseHB0
IFP residues
ALA90 ARG74 GLY85 LEU73 LYS89 MET70 PHE83 PRO212 PRO213 SER86 SER87 VAL88
Current overlap10Native recall0.83
Jaccard0.56RMSD-
HB strict0Strict recall-
HB same residue+role0HB role recall-
HB same residue0HB residue recall-

HB · H-bonds

No hb · h-bonds detected for this pose.

PI · π–π interactions

No pi · π–π interactions detected for this pose.

HY · Hydrophobic contacts

CLASH · Clashes

All stored poses for this docking hit

PoseFinal rankInter normScoreHBCTCT overlapCT recallHB role rec.RMSDExcluded
1005 3.6218887364310652 -0.72073 -23.298 1 16 10 0.83 - - no Open
1010 4.278360828137885 -0.746547 -22.2109 1 15 9 0.75 - - no Open
1006 4.511273022426328 -0.825431 -25.6105 1 14 7 0.58 - - no Open
1007 5.290130525276083 -0.772922 -23.3886 2 16 8 0.67 - - no Open
1008 5.893014819548256 -0.678186 -21.1556 0 16 10 0.83 - - no Current
1003 6.291564314235465 -0.870649 -26.7266 2 14 9 0.75 - - no Open
1004 56.34598364722124 -0.626927 -19.5823 1 12 8 0.67 - - no Open
1000 5.5181228151111785 -0.803077 -25.283 1 16 10 0.83 - - yes Open
999 7.12839410907742 -0.841927 -25.5332 2 16 9 0.75 - - yes Open
1002 7.871928203862885 -0.706688 -21.075 1 14 7 0.58 - - yes Open
1009 62.38639282216786 -0.794191 -22.3471 2 14 7 0.58 - - yes Open
1001 63.53589752418739 -0.803796 -22.8534 3 14 7 0.58 - - yes Open

Molecular metrics

RDKit SASA burial, strain energy (MMFF94s), ligand efficiency and fit quality for this docking pose.
⚠ Not yet computed
Molecular metrics have not been computed for this pose yet. This page now reads only cached values; use a background recompute when you want fresh metrics without slowing the UI.