FAIRMol

Z49732247

Pose ID 11493 Pose 650

DB fairmolDocking pose analysis is being read from this database.
Molecular metrics status: missing
Molecular metrics have not been computed yet for this pose.
No cached metrics
T17
T. brucei TR (Doorstop site) T. brucei Doorstop site
Ligand Z49732247
PDB5S9T

3D complex viewer

Strict H-bonds Permissive H-bonds
Viewer legend
Protein receptor
Pocket residues
Cofactor context
Docked ligand
Overall assessment
Weak Metrics pending
Promising but geometrically suspicious
Binding strong Geometry low Native mixed SASA pending
Strain ΔE
28.2 kcal/mol
Protein clashes
0
Internal clashes
11
Native overlap
contact recall 0.33, Jaccard 0.18, H-bond role recall 0.00
Burial
87%
Reason: 11 internal clashes
11 intramolecular clashes

Interaction summary

HB 7 HY 10 PI 1 CLASH 0

HB · H-bonds

Mode: strict. Count shows atom-level H-bonds; unique residues in summary: 0.

PI · π–π interactions

Native π–π recall is disabled because no explicit native π–π reference was stored.

HY · Hydrophobic contacts

CLASH · Clashes

No clash · clashes detected for this pose.
Final rank4.942Score-18.819
Inter norm-0.976Intra norm0.158
Top1000noExcludedyes
Contacts14H-bonds7
Artifact reasonexcluded; geometry warning; 11 clashes; 4 protein clashes; moderate strain Δ 28.2
Residues
ALA284 ARG228 ARG287 GLY196 GLY197 GLY229 GLY286 ILE199 ILE226 LEU227 PHE198 PHE230 SER200 TYR221

Native ligand reference

★ reference
Interaction fingerprint calculated directly from the uploaded native ligand without docking. Current H-bond mode: strict.
Name5S9TContacts12
PoseOpen native poseHB0
IFP residues
ALA365 ARG228 ARG331 GLY229 LEU332 LEU334 MET333 PHE198 PHE230 SER364 THR374 VAL366
Current overlap4Native recall0.33
Jaccard0.18RMSD-
HB strict0Strict recall0.00
HB same residue+role0HB role recall0.00
HB same residue0HB residue recall0.00

Protein summary

1033 residues
Protein targetT17Atoms15160
Residues1033Chains2
Residue summaryVAL:1536; LEU:1387; LYS:1386; ILE:1064; GLU:900; THR:868; ARG:816; PHE:800; ALA:780; ASN:700; PRO:686; GLY:672; SER:616; TYR:588; ASP:528; MET:408

Receptor context

2 kept / 0 excluded
Receptor context filtering: interactions and SASA are computed against protein atoms plus allowed cofactors/ions. Native ligand-like HETATM partners are excluded from scoring.
Kept context 2 Excluded HETATM 0
Kept cofactors / ions
A:FAD501 B:FAD501

All stored poses for this docking hit

PoseFinal rankInter normScoreHBCTCT overlapCT recallHB role rec.RMSDExcluded
650 4.941884263181172 -0.975829 -18.819 7 14 4 0.33 0.00 - yes Current

Molecular metrics

RDKit SASA burial, strain energy (MMFF94s), ligand efficiency and fit quality for this docking pose.
⚠ Not yet computed
Molecular metrics have not been computed for this pose yet. This page now reads only cached values; use a background recompute when you want fresh metrics without slowing the UI.