FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T04T05T07T21
Z56786752 0.946 0.892 3 0.85 0.87 0.95
Z56786752 0.841 0.841 1 0.84

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56786752 T21
native IFP available
T21
selection_import_t21
0.946 1.000 0.847 native_similarity final_rank_score -24.9451 -1.29144 15 11 Pose
Z56786752 T07
native IFP available
T07
selection_import_t07
0.874 1.000 0.641 native_similarity final_rank_score -29.3357 -1.58974 15 6 Pose
Z56786752 T05
native IFP available
T05
selection_import_t05
0.855 1.000 0.586 native_similarity final_rank_score -27.7304 -1.52158 13 9 Pose
Z56786752 T04
native IFP available
T04
selection_import_t04
0.841 1.000 0.545 native_similarity final_rank_score -28.7921 -1.37069 11 4 Pose