FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
Reset
1 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T10T12T17T21
Z55466823 0.949 0.896 4 0.94 0.95 0.77 0.92

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z55466823 T12
native IFP available
T12
selection_import_t12
0.949 1.000 0.854 native_similarity final_rank_score -29.6107 -1.17655 16 15 Pose
Z55466823 T10
native IFP available
T10
selection_import_t10
0.940 1.000 0.829 native_similarity final_rank_score -22.4069 -1.03848 17 16 Pose
Z55466823 T21
native IFP available
T21
selection_import_t21
0.923 1.000 0.780 native_similarity final_rank_score -24.0552 -0.969471 16 13 Pose
Z55466823 T17
native IFP available
T17
selection_import_t17
0.773 1.000 0.352 native_similarity final_rank_score -21.0301 -0.834271 17 4 Pose