FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
Reset
2 compounds in matrix 14 best compound-target hits listed 14 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T05T07T08T09T11T12T13T14T15T17T20T21T22
Z49605060 0.921 0.868 3 0.92 0.79 0.90
Z49605060 0.914 0.839 11 0.85 0.87 0.85 0.82 0.74 0.91 0.87 0.78 0.83 0.91 0.81

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z49605060 T11
native IFP available
T11
selection_import_t11
0.921 1.000 0.773 native_similarity final_rank_score -27.0004 -0.908332 16 7 Pose
Z49605060 T21
native IFP available
T21
selection_import_t21
0.914 1.000 0.754 native_similarity final_rank_score -31.045 -1.01023 17 12 Pose
Z49605060 T12
native IFP available
T12
selection_import_t12
0.908 1.000 0.737 native_similarity final_rank_score -21.5961 -1.03551 18 9 Pose
Z49605060 T20
native IFP available
T20
selection_import_t20
0.898 1.000 0.710 native_similarity final_rank_score -19.456 -0.850416 11 12 Pose
Z49605060 T05
native IFP available
T05
selection_import_t05
0.867 1.000 0.621 native_similarity final_rank_score -20.0297 -1.05953 12 5 Pose
Z49605060 T13
native IFP available
T13
selection_import_t13
0.866 1.000 0.618 native_similarity final_rank_score -35.5375 -1.09378 24 7 Pose
Z49605060 T03
native IFP available
T03
selection_import_t03
0.847 1.000 0.563 native_similarity final_rank_score -32.6346 -1.06094 14 3 Pose
Z49605060 T07
native IFP available
T07
selection_import_t07
0.845 1.000 0.558 native_similarity final_rank_score -31.9367 -1.28056 14 8 Pose
Z49605060 T17
native IFP available
T17
selection_import_t17
0.831 1.000 0.516 native_similarity final_rank_score -23.8179 -0.885977 15 8 Pose
Z49605060 T08
native IFP available
T08
selection_import_t08
0.823 1.000 0.494 native_similarity final_rank_score -36.6954 -1.2299 11 12 Pose
Z49605060 T22
native IFP available
T22
selection_import_t22
0.809 1.000 0.453 native_similarity final_rank_score -30.9661 -1.195 24 12 Pose
Z49605060 T15
native IFP available
T15
selection_import_t15
0.786 1.000 0.388 native_similarity final_rank_score -19.2394 -0.890577 16 9 Pose
Z49605060 T14
native IFP available
T14
selection_import_t14
0.780 1.000 0.372 native_similarity final_rank_score -27.1637 -0.87843 14 5 Pose
Z49605060 T09
native IFP available
T09
selection_import_t09
0.743 1.000 0.267 native_similarity final_rank_score -26.3867 -1.06546 14 8 Pose