FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 18 best compound-target hits listed 18 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T03T06T07T08T09T10T11T12T13T14T15T16T17T18T20T21
TC394 0.950 0.851 11 0.83 0.85 0.85 0.95 0.86 0.93 0.84 0.77 0.76 0.79 0.93
TC394 0.918 0.797 7 0.92 0.76 0.80 0.79 0.76 0.73 0.83

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
TC394 T10
native IFP available
T10
selection_import_t10
0.950 1.000 0.858 native_similarity final_rank_score -31.4819 -1.07692 19 14 Pose
TC394 T12
native IFP available
T12
selection_import_t12
0.932 1.000 0.807 native_similarity final_rank_score -28.5316 -1.04699 18 12 Pose
TC394 T21
native IFP available
T21
selection_import_t21
0.932 1.000 0.807 native_similarity final_rank_score -27.0988 -0.989229 18 11 Pose
TC394 T01
native IFP available
T01
selection_import_t01
0.918 1.000 0.764 native_similarity final_rank_score -27.2825 -0.883414 19 5 Pose
TC394 T11
native IFP available
T11
selection_import_t11
0.859 1.000 0.597 native_similarity final_rank_score -27.6245 -1.01455 12 5 Pose
TC394 T07
native IFP available
T07
selection_import_t07
0.849 1.000 0.570 native_similarity final_rank_score -34.976 -1.22973 18 7 Pose
TC394 T08
native IFP available
T08
selection_import_t08
0.849 1.000 0.570 native_similarity final_rank_score -26.6215 -1.08846 18 7 Pose
TC394 T13
native IFP available
T13
selection_import_t13
0.839 1.000 0.539 native_similarity final_rank_score -28.7461 -0.95126 15 7 Pose
TC394 T02
native IFP available
T02
selection_import_t02
0.832 1.000 0.519 native_similarity final_rank_score -27.6435 -0.950902 17 4 Pose
TC394 T20
native IFP available
T20
selection_import_t20
0.831 1.000 0.517 native_similarity final_rank_score -17.04 -0.662194 10 7 Pose
TC394 T06
native IFP available
T06
selection_import_t06
0.798 1.000 0.424 native_similarity final_rank_score -20.0129 -0.831216 18 3 Pose
TC394 T18
native IFP available
T18
selection_import_t18
0.789 1.000 0.397 native_similarity final_rank_score -17.7079 -0.712441 15 5 Pose
TC394 T09
native IFP available
T09
selection_import_t09
0.785 1.000 0.386 native_similarity final_rank_score -29.0382 -0.991983 18 5 Pose
TC394 T15
native IFP available
T15
selection_import_t15
0.772 1.000 0.348 native_similarity final_rank_score -25.4528 -0.909325 9 7 Pose
TC394 T14
native IFP available
T14
selection_import_t14
0.761 1.000 0.317 native_similarity final_rank_score -26.0374 -1.00429 16 10 Pose
TC394 T03
native IFP available
T03
selection_import_t03
0.760 1.000 0.313 native_similarity final_rank_score -29.4518 -1.03597 12 6 Pose
TC394 T17
native IFP available
T17
selection_import_t17
0.756 1.000 0.302 native_similarity final_rank_score -22.3666 -0.81073 17 4 Pose
TC394 T16
native IFP available
T16
selection_import_t16
0.729 1.000 0.225 native_similarity final_rank_score -22.5863 -0.805084 13 7 Pose