FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 16 best compound-target hits listed 16 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T03T06T07T08T09T10T11T12T13T14T15T17T18T21
TC392 0.955 0.861 9 0.92 0.86 0.80 0.79 0.96 0.86 0.88 0.79 0.91
TC392 0.935 0.829 7 0.83 0.85 0.87 0.93 0.76 0.76 0.79

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
TC392 T10
native IFP available
T10
selection_import_t10
0.955 1.000 0.873 native_similarity final_rank_score -27.7999 -1.07531 17 11 Pose
TC392 T12
native IFP available
T12
selection_import_t12
0.935 1.000 0.814 native_similarity final_rank_score -29.3772 -1.01002 16 12 Pose
TC392 T01
native IFP available
T01
selection_import_t01
0.918 1.000 0.764 native_similarity final_rank_score -26.2435 -0.849466 19 7 Pose
TC392 T21
native IFP available
T21
selection_import_t21
0.908 1.000 0.736 native_similarity final_rank_score -23.1893 -0.929592 16 10 Pose
TC392 T13
native IFP available
T13
selection_import_t13
0.877 1.000 0.648 native_similarity final_rank_score -26.5489 -1.04133 21 9 Pose
TC392 T08
native IFP available
T08
selection_import_t08
0.870 1.000 0.630 native_similarity final_rank_score -33.1094 -1.19994 18 9 Pose
TC392 T11
native IFP available
T11
selection_import_t11
0.859 1.000 0.597 native_similarity final_rank_score -26.3287 -0.962424 12 5 Pose
TC392 T03
native IFP available
T03
selection_import_t03
0.857 1.000 0.591 native_similarity final_rank_score -28.8915 -0.992564 18 4 Pose
TC392 T07
native IFP available
T07
selection_import_t07
0.849 1.000 0.570 native_similarity final_rank_score -35.2098 -1.27835 18 6 Pose
TC392 T02
native IFP available
T02
selection_import_t02
0.832 1.000 0.519 native_similarity final_rank_score -24.7932 -0.90485 17 3 Pose
TC392 T06
native IFP available
T06
selection_import_t06
0.795 1.000 0.415 native_similarity final_rank_score -20.8455 -0.859939 19 3 Pose
TC392 T18
native IFP available
T18
selection_import_t18
0.793 1.000 0.408 native_similarity final_rank_score -19.5389 -0.719092 14 5 Pose
TC392 T17
native IFP available
T17
selection_import_t17
0.786 1.000 0.389 native_similarity final_rank_score -21.1831 -0.837279 19 6 Pose
TC392 T09
native IFP available
T09
selection_import_t09
0.785 1.000 0.386 native_similarity final_rank_score -25.8374 -0.930123 18 6 Pose
TC392 T14
native IFP available
T14
selection_import_t14
0.765 1.000 0.327 native_similarity final_rank_score -21.5094 -0.858206 14 7 Pose
TC392 T15
native IFP available
T15
selection_import_t15
0.764 1.000 0.326 native_similarity final_rank_score -27.4818 -1.01686 11 9 Pose